Hazard Info

Health Hazards (mixtures)

Health Hazard: Acute Toxicity - Oral

Hazard Category: Category 1
Signal Word: Danger
Hazard Statement: Fatal if swallowed.
Definition:Oral LD50=5 mg/kg bodyweight.
Symbols: hazard: , transport*: (click image to enlarge)
Hazard Category: Category 2
Signal Word: Danger
Hazard Statement: Fatal if swallowed.
Definition:Oral LD50>5 but <50 mg/kg bodyweight.
Symbols: hazard: , transport*: (click image to enlarge)
Hazard Category: Category 3
Signal Word: Danger
Hazard Statement: Toxic if swallowed.
Definition:Oral LD50>50 but <300 mg/kg bodyweight.
Symbols: hazard: , transport*: (click image to enlarge)
Hazard Category: Category 4
Signal Word: Warning
Hazard Statement: Harmful if swallowed.
Definition:Oral LD50 >300 but <2000 mg/kg bodyweight.
Symbols: hazard: (click image to enlarge), transport: n/a
Hazard Category: Category 5
Signal Word: Warning
Hazard Statement: May be harmful if swallowed.
Definition:Oral LD50>2000 but <5000 mg/kg bodyweight.
Symbols: n/a

Health Hazard: Acute Toxicity - Dermal

Hazard Category: Category 1
Signal Word: Danger
Hazard Statement: Fatal in contact with skin.
Definition:Dermal LD50=50 mg/kg bodyweight.
Symbols: hazard: , transport*: (click image to enlarge)
Hazard Category: Category 2
Signal Word: Danger
Hazard Statement: Fatal in contact with skin.
Definition:Dermal LD50 >50 but <200 mg/kg bodyweight.
Symbols: hazard: , transport*: (click image to enlarge)
Hazard Category: Category 3
Signal Word: Danger
Hazard Statement: Toxic in contact with skin.
Definition: Dermal LD50> 200 but <1000 mg/kg bodyweight.
Symbols: hazard: , transport*: (click image to enlarge)
Hazard Category: Category 4
Signal Word: Warning
Hazard Statement: Harmful in contact with skin.
Definition: Dermal LD50>1000 but <2000 mg/kg bodyweight.
Symbols: hazard: (click image to enlarge), transport: n/a
Hazard Category: Category 5
Signal Word: Warning
Hazard Statement: May be harmful in contact with skin.
Definition: Dermal LD50>2000 but <5000 mg/kg bodyweight.
Symbols: n/a

Health Hazard: Acute Toxicity - Inhalation

Hazard Category: Category 1
Signal Word: Danger
Hazard Statement: Fatal if inhaled.
Definition: Inhalation (vapour) LC50=0.5 mg/l, or ·Inhalation (dust/mist) LC50=0.05 mg/l.
Symbols: hazard: , transport*: (click image to enlarge)
Hazard Category: Category 2
Signal Word: Danger
Hazard Statement: Fatal if inhaled.
Definition: Inhalation (gas) LC50 >100 but <500 ppm, or ·Inhalation (vapour) LC50> 0.5 but <2.0 mg/l, or ·Inhalation (dust/mist) LC50>0.05 but =0.5 mg/l.
Symbols: hazard: , transport*: (click image to enlarge)
Hazard Category: Category 3
Signal Word: Danger
Hazard Statement: Toxic if inhaled.
Definition: Inhalation (gas) LC50>500 but <2500 ppm, or· Inhalation (vapour) LC50>2 but <10.0 mg/l, or· Inhalation (dust/mist) LC50>0.5 but <1.0 mg/l.
Symbols: hazard: , transport*: (click image to enlarge)
Hazard Category: Category 4
Signal Word: Warning
Hazard Statement: Harmful if inhaled.
Definition: Inhalation (gas) LC50>2500 but <5000 ppm, or· Inhalation (vapour) LC50>10 but <20 mg/l, or· Inhalation (dust/mist) LC50>1 but <5 mg/l.
Symbols: hazard: (click image to enlarge)
Hazard Category: Category 5
Signal Word: Warning
Hazard Statement: May be harmful if inhaled.
Definition: Inhalation (gas, vapour and/or dust/mist) LC50in the equivalent range of the oral and dermal LD50(i.e., 2000-5000 mg/kg bodyweight).
Symbols: n/a

Additional Information: When classifying your product for Category 5, consider the following questions: is there reliable information available indicating significant toxicity effects in humans?; or·Was any mortality observed when tested up to Category 4 values by the oral, inhalation or dermal routes?; or·Is there expert judgment that confirms significant clinical signs of toxicity, when tested up to Category 4 values, except for diarrhea, piloerection or an ungroomed appearance?; or·Is there expert judgment that confirms reliable information indicating the potential for significant acute effects from other animals?

Health Hazard: Skin Corrosion/Irritation

Hazard Category: Category 1A
Signal Word: Danger
Hazard Statement: Causes severe skin burns and eye damage.
Definition: Where responses are noted following up to 3 minutes exposure and up to 1 hour observation. Existing human experience showing irreversible damage to skin, · Existing animal observations indicating skin corrosion after single or repeated exposure,· In vitro data,· Information available from structurally related compounds, · pH extremes of =2 or =11.5, including consideration of acid/alkali reserve capacity, if appropriate ·Destruction of skin in one or more test animals.
Symbols: hazard: , transport*: (click image to enlarge)
Hazard Category: Category 1B
Signal Word: Danger
Hazard Statement: Causes severe skin burns and eye damage.
Definition: Where responses are described following exposure bwetween 3 minutes and 1 hour and observations up to 14 days.
Symbols: hazard: , transport*: (click image to enlarge)
Hazard Category: Category 1C
Signal Word: Danger
Hazard Statement: Causes severe skin burns and eye damage.
Definition: Where responses occur after exposures between 1 hour and 4 hours and observations up to 14 days.
Symbols: hazard: , transport*: (click image to enlarge)
Hazard Category: Category 2
Signal Word: Warning
Hazard Statement: Causes skin irritation.
Definition: Existing human experience and data, single or repeated exposure,*Existing animal observations including single or repeated exposure,*In vitro data,*Information available from structurally related compounds,*Skin irritation data from an animal study.
Symbols: hazard: (click image to enlarge)
Hazard Category: Category 3
Signal Word: Warning
Hazard Statement: Causes mild skin irritation.
Definition: Mild irritation.
Symbols: n/a

Health Hazard: Eye Damage/Eye Irritation

Hazard Category: Category 1
Signal Word: Danger
Hazard Statement: Causes serious eye damage.
Definition: Does the substance have potential to cause irreversible eye damage (serious eye damage) considering:· Existing human experience, · Existing animal observations including single or repeated exposure,· In vitro data,· Information available from structurally related compounds,· pH extremes of =2 or =11.5, including consideration of acid/alkali reserve capacity, if appropriate ·Irreversible eye damage in one or more test animals.
Symbols: hazard (click image to enlarge)
Hazard Category: Category 2A
Signal Word: Warning
Hazard Statement: Causes serious eye irritation.
Definition: Existing human experience and data, single or repeated exposure,· Existing animal observations including single or repeated exposure, · In vitro data,· Information available from structurally related compounds, · Eye irritation data from an animal study.
Symbols: hazard: (click image to enlarge)
Hazard Category: Category 2B
Signal Word: Warning
Hazard Statement: Causes eye irritation.
Definition: Mild irritant.
Symbols: n/a

Health Hazard: Sensitization-Respiratory

Hazard Category: Category 1
Signal Word: Danger
Hazard Statement: May cause allergy or asthma symptoms or breathing difficulties if inhaled.
Definition: Evidence in humans that the substance can induce specific respiratory hypersensitivity, and/or are there positive results from an appropriate animal test.
Symbols: hazard: (click image to enlarge)

Health Hazard: Sensitization-Skin

Hazard Category: Category 1
Signal Word: Warning
Hazard Statement: May cause an allergic skin reaction.
Definition: Evidence in humans that the substance can induce sensitization by skin contact in a substantial number of persons or ·Are there positive results from an appropriate animal test.
Symbols: hazard: (click image to enlarge)

Health Hazard: Germ Cell Mutagenicity

Hazard Category: Category 1
Signal Word: Danger
Hazard Statement: May cause genetic defects < state route of exposure it it is conclusively proven that no other routes of exposure cause the hazard>.
Definition: Known to induce heritable mutations in germ cells of humans, or · Should it be regarded as if it induces heritable mutations in the germ cells of humans Application of criteria needs expert judgment in a weight of evidence approach.
Symbols: hazard: (click image to enlarge)
Hazard Category: Category 2
Signal Word: Warning
Hazard Statement: Suspected of causing genetic defects < state route of exposure it it is conclusively proven that no other routes of exposure cause the hazard>.
Definition: According to the criteria, the substance causes concern for humans owing to the possibility that it may induce heritable mutations in the germ cells of humans Application of criteria needs expert judgment in a weight of evidence approach.
Symbols: hazard: (click image to enlarge)

Health Hazard: Carcinogenicity

Hazard Category: Category 1
Signal Word: Danger
Hazard Statement: May cause genetic defects < state route of exposure it it is conclusively proven that no other routes of exposure cause the hazard>.
Definition: Known to have carcinogenic potential for humans, or presumed to have carcinogenic potential for humans Application of the criteria needs expert judgment in a strength and weight of evidence approach.
Symbols: hazard: (click image to enlarge)
Hazard Category: Category 2
Signal Word: Warning
Hazard Statement: Suspected of causing cancer < state route of exposure it it is conclusively proven that no other routes of exposure cause the hazard>.
Definition: The substance a suspected human carcinogen Application of the criteria needs expert judgment in a strength and weight of evidence approach.
Symbols: hazard: (click image to enlarge)

Health Hazard: Reproductive Toxicity

Hazard Category: Category 1
Signal Word: Danger
Hazard Statement: May damage fertility or the unborn child < state specific effect if known > << state route of exposure of it is conclusively proven that no other routes of exposure cause the hazard >>.
Definition: A known human reproductive toxicant Or A presumed human reproductive toxicant Application of the criteria needs expert judgment in a weight of evidence approach.
Symbols: hazard: (click image to enlarge)
Hazard Category: Category 2
Signal Word: Warning
Hazard Statement: Suspected of damaging fertility or the unborn child < state specific effect if known > << state route of exposure of it is conclusively proven that no other routes of exposure cause the hazard >>.
Definition: The substance is a suspected human reproductive toxicant Application of the criteria needs expert judgment in a weight of evidence approach.
Symbols: hazard: (click image to enlarge)
Hazard Category: Effects on or via Lactation
Signal Word: n/a
Hazard Statement: May cause harm to breast-fed children.
Definition: The substance, according to the criteria cause concern for the health of breastfed children.
Symbols: n/a

Health Hazard: STOST - Single Exposure

Hazard Category: Category 1
Signal Word: Danger
Hazard Statement: Causes damage to organs < or state all organs affected in known > << state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard >>.
Definition: The substance produces significant toxicity in humans or it can be presumed to have the potential to produce significant toxicity in humans on the basis of evidence from studies in experimental animals Application of the criteria needs expert judgement in a weight of evidence approach.
Symbols: hazard: (click image to enlarge)
Hazard Category: Category 2
Signal Word: Warning
Hazard Statement: May cause damage to organs < or state all organs affected in known > << state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard >>.
Definition: The substance is presumed to have the potential to be harmful to human health on the basis of evidence from studies in experimental animals Application of the criteria needs expert judgement in a weight of evidence approach.
Symbols: hazard: (click image to enlarge)
Hazard Category: Category 3
Signal Word: Warning
Hazard Statement: May cause respiratory irritation. OR; May cause drowsiness and dizziness.
Definition: The substance or mixture produces narcotic effects or respiratory tract irritation Application of the criteria needs expert judgement in a weight of evidence approach.
Symbols: hazard: (click image to enlarge)

Health Hazard: STOST - Repeated Exposure

Hazard Category: Category 1
Signal Word: Danger
Hazard Statement: Causes damage to organs < or state all organs affected in known > through prolonged or repeated exposure << state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard >>.
Definition: The substance produce significant toxicity in humans or can be presumed to have the potential to produce significant toxicity in humans on the basis of evidence from studies in experimental animals Application of the criteria needs expert judgement in a weight of evidence approach.
Symbols: hazard: (click image to enlarge)
Hazard Category: Category 2
Signal Word: Warning
Hazard Statement: May cause damage to organs < or state all organs affected in known > through prolonged or repeated exposure << state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard >>.
Definition: The substance be presumed to have the potential to be harmful to human health on the basis of evidence from studies in experimental animals Application of the criteria needs expert judgement in a weight of evidence approach.
Symbols: hazard: (click image to enlarge)

Health Hazard: Aspiration Hazard

Hazard Category: Category 1
Signal Word: Danger
Hazard Statement: May be fatal if swallowed and enters airways.
Definition: There is practical experience in humans from reliable and good quality evidence, for example, certain hydrocarbons, turpentine and pine oil, or the substance is a hydrocarbon with a kinematic viscosity of 20.5mm2/s or less measured at40 °C.
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Hazard Category: Category 2
Signal Word: Warning
Hazard Statement: May be harmful if swallowed and enters airways.
Definition: There is evidence causing concern based on animal studies and expert judgment, and the substance has a kinematic viscosity of 14 mm2/s or less, measured at 40 °C.
Symbols: hazard: (click image to enlarge)

Health Hazard: Hazardous to the Aquatic Environment - Acute Hazard

Hazard Category: Category 1
Signal Word: Warning
Hazard Statement: Very toxic to aquatic life.
Definition: 96 hr LC50(fish) = 1 mg/l, and/or 48 hr EC50(crustacea) =1 mg/l, and/or ·72 or 96 hr ErC50(algae or other aquatic plants) = 1 mg/l.
Symbols: hazard: , transport*: (click image to enlarge)
Hazard Category: Category 2
Signal Word: n/a
Hazard Statement: Toxic to aquatic life.
Definition: 96 hr LC50(fish) =10 mg/l, and/or 48 hr EC50(crustacea) =10 mg/l, and/or·72 or 96 hr EC50(algae or other aquatic plants) =10 mg/l.
Symbols: n/a
Hazard Category: Category 3
Signal Word: n/a
Hazard Statement: Harmful to aquatic life.
Definition: 96 hr LC50(fish) =100 mg/l, and/or 48 hr EC50(crustacea) =100 mg/l, and/or 72 or 96 hr EC50(algae or other aquatic plants) =100 mg/l.
Symbols: n/a

Health Hazard: Hazardous to the Aquatic Environment - Chronic Hazard

Hazard Category: Category 1
Signal Word: Warning
Hazard Statement: Very toxic to aquatic life with long lasting effects.
Definition: 96 hr LC50(fish) =1 mg/l, and/or 48 hr EC50(crustacea) =1 mg/l, and/or·72 or 96 hr ErC50(algae or other aquatic plants) =1 mg/l AND it lacks the potential to rapidly degrade and/or has the potential to bioaccumulate (BCF=500 or if absent, log Kow =4).
Symbols: hazard: (click image to enlarge)
Hazard Category: Category 2
Signal Word: n/a
Hazard Statement: Toxic to aquatic life with long lasting effects.
Definition: 96 hr LC50(fish) =10 mg/l, and/or 48 hr EC50(crustacea) =10 mg/l, and/or·72 or 96 hr EC50(algae or other aquatic plants) =10 mg/l AND it lacks the potential to rapidly degrade and/or has the potential to bioaccumulate (BCF=500 or if absent, log Kow =4). Chronic unless NOEC(s) >1 mg/1.
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Hazard Category: Category 3
Signal Word: n/a
Hazard Statement: Harmful to aquatic life with long lasting effects.
Definition: 96 hr LC50(fish) =100 mg/l, and/or 48 hr EC50(crustacea) =100 mg/l, and/or 72 or 96 hr EC50(algae or other aquatic plants) =100 mg/l AND lacks the potential to rapidly degrade and/or has the potential to bioaccumulate (BCF=500 or if absent, log Kow =4) Chronic unless NOEC(s) >1 mg/1.
Symbols: n/a
Hazard Category: Category 4
Signal Word: n/a
Hazard Statement: May cause long lasting harmful effects to aquatic life.
Definition: Is poorly soluble with no acute toxicity and lacks the potential to rapidly degrade and has the potential to bioaccumulate (BCF=500 or if absent, log Kow =4).
Symbols: n/a

Bibliography:
Health Hazard information:
Health and environmental hazards: classification criteria for substances. UNECE. 2005. http://www.unece.org/trans/danger/publi/ghs/GHS_presentations/ English/Rev01/health_env_sub_e.pdf

Health and environmental hazards: classification criteria for mixtures. UNECE. 2005. http://www.unece.org/trans/danger/publi/ghs/GHS_presentations/ English/Rev01/health_env_mix_e.pdf

GHS Definitions. Health and Safety Authority(HSA). http://www.hsa.ie/files/file_20070124011004GHS%20definitions.htm

Transport information:
Globally Harmonized System of Classification. First Revised Edition. Annex 1: Allocation of Label Elements. ST/SG/AC.10/30/Rev.1 UNECE. 2005. http://www.unece.org/trans/danger/publi/ghs/ghs_rev01/English/05e_annex1.pdf

A Guide to The Globally Harmonized System of Classification and Labeling of Chemicals (GHS) OSHA. 2006, September 11. http://www.osha.gov/dsg/hazcom/ghs.html